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What drugs are found due to side effects?

2018-11-07
 

https://en.wikipedia.org/wiki/Galega_officinalis

 

a classic example of metformin, which has the same broad and precise pharmacological effects as aspirin. Metformin is used to treat type 2 diabetes, anti-tumor, and treatment of polycystic ovary syndrome. It is now found that metformin can also delay aging.

 

In the 1920s (that is, when insulin was discovered), American herders found that their livestock had eaten a newly introduced pasture, and that state was a bit abnormal. Symptoms of pulmonary edema, hypotension, and even paralysis and death can occur. This newly introduced grass is called  Galega officinalis, which comes from Europe, so it is quickly listed as a harmful plant by most states in the United States. The German scientist Donrett carefully analyzed the chemical composition of this pasture and found that an  guanidines material ( Galega officinalis/galegine, also known as isopentenyl) is the chief culprit of livestock death, and this substance Therefore, it is possible to poison livestock because it can lower blood glucose very violently.

 

Galega officinalis Originally produced in the Middle East, it was later introduced to Europe and West Asia. It was used as a forage in the early days and was once used as a medicinal material for livestock, but it was quickly found to be harmful to livestock and was banned from planting. German scientist Donrett purified the galegine from Galega officinalis, and later modified the chemical structure of the galegine to obtain metformin. Reduced side effects and improved clinical treatment, this is the birth of a generation of the god drug - metformin.