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Deceived the world for more than ten years, the American stem cell "academic expert" went down the altar



Suspected forgery and falsification of experimental data was retracted 31 articles -


"We recently used a new technique to answer the presence of stem cells in adult hearts. The results of the experiment showed that non-cardiac cells in adult mice do not form cardiomyocytes after being in homeostasis and suffering damage." Shanghai Life, Chinese Academy of Sciences Zhou Bin, a researcher at the Institute of Biochemistry and Cell Biology at the Institute of Science, said when he talked about the retraction paper of the former Harvard Medical School professor and director of the Center for Regenerative Medicine, Piero Anvisa.


According to a recent report by the US "Retraction Watch" and other websites, Harvard Medical School and its affiliated Brigham and Women's Hospital recommended that the papers of Anvisa be withdrawn from multiple medical journals. The number of retracted papers reached 31, all of which were suspected of falsifying and falsifying experimental data.


The 78-year-old  Dr. Anversa popularized published two papers in 2001 and 2003 respectively. contrary to scientific consensus, heart muscle could be regenerated. If true, the research would have had enormous significance for patients worldwide.. Dr. Anversa popularized was once thought to have initiated heart stem cell therapy and hosted 110 projects.


However, many laboratories in the world tried to repeat the result but failed. But that may also prevent the visa laboratory from continuing to publish papers and apply for funds.


However, many laboratories around the world tried to repeat this result but failed. But this does not prevent Dr. Anversa popularized  Lab from continuing to publish papers and apply for funds.


" can't  repeated but it doesn't mean that his conclusion is wrong. Science pays attention to the evidence." Zhou Bin said that until 2014, the team of cardiovascular biologist Geoffrey Mokentin of the Cincinnati Children's Hospital Medical Center, USA, first proved by genetic experiments. stem cell(c-kit) in the rat heart almost never produce new cardiomyocytes.


"In addition to c-kit cells, it is not clear whether other types of stem cells exist in adult hearts. Our latest experiment is to answer a broader question, whether there are stem cells in adult hearts. For the time being, our research group's experiments The data does not support this view." Zhou Bin said.


Why has a wrong study and results been followed by people for nearly 20 years, until now it has been thoroughly exposed? "In fact, there have always been doubts, but it was because many laboratories could not produce evidence of genetic experiments, so it is not easy to give conclusions directly." Zhou Bin said.


"Dr. Anversa popularized has long been regarded as the authority in the field of cardiac stem cells. The different opinions expressed by ordinary researchers are likely to be ignored. The results of Moore's experiment only let the parties really pay attention to this matter." Say. Moore is also a heavyweight in the industry and is known as the new leader in cardiovascular science.


According to reports, the opinion of a former member of the Anvisa laboratory, who did not want to be named, also supported the analysis of Zuo Wei. The person said that at any meeting, as long as someone questioned his hypothesis, it would be called "idiot" by Anvisa. In his laboratory, the person who questioned his hypothesis would be immediately dismissed.


In addition, this result is inseparable from the review process of the paper. When the paper is published, it will be reviewed by peer experts. However, most experts will avoid the name of Anvisa. Many experimental places are defaulted to Verify, or no verification required. On the contrary, those papers that question his hypothesis, once sent to Anvisa, will undoubtedly be ruthlessly criticized and suppressed, without the opportunity to publish.


Expert comment :


It is understood that in the past ten years, Anvisa has applied for more than 50 million US dollars in the name of the so-called "myocardial stem cells". In other countries, including China, the total investment in this research field is far beyond this. For more than a decade, countless manpower, material resources, and financial resources have been invested, and in the end, only a bunch of papers that cannot be justified and have no practical significance have been exchanged. At home and abroad, there are still people working on the basis of the Anvisa experiment, or doing research related to his experimental results. This is not only a waste of social resources, but also a delay in the research process in this field.


(commenter: Professor Zuo Wei, School of medicine, Tongji University)